Abnormal epidermal barrier in the pathogenesis of psoriasis
R Wolf, E Orion, E Ruocco, V Ruocco - Clinics in dermatology, 2012 - Elsevier
Almost 2 decades ago, Williams and Elias suggested a unifying concept for the
pathogenesis of disorders of cornification, according to which the integrity of the epidermal
barrier and its effective function is an important factor in the regulation of epidermal DNA
synthesis. Interference with the barrier integrity or function will result in epidermal
hyperplasia and may be the primary event leading to hyperproliferative skin diseases, such
as psoriasis. We have analyzed alterations to several structures of the epidermal barrier that …
pathogenesis of disorders of cornification, according to which the integrity of the epidermal
barrier and its effective function is an important factor in the regulation of epidermal DNA
synthesis. Interference with the barrier integrity or function will result in epidermal
hyperplasia and may be the primary event leading to hyperproliferative skin diseases, such
as psoriasis. We have analyzed alterations to several structures of the epidermal barrier that …