T-cell activation is potentiated by cytokines released by lesional psoriatic, but not normal, epidermis
EY Chang, C Hammerberg, G Fisher… - Archives of …, 1992 - jamanetwork.com
• Background and Design.—T-cell activation appears to be critical for the maintenance of
psoriatic lesions. In this study, we determined whether cytokines released by epidermal cells
from psoriatic lesions are providing signals that result in propagation of intralesional T-cell
activation. Supernatants were obtained from epidermal cell cultures derived from skin biopsy
specimens of psoriatic patients and normal subjects. These supernatants were added to
purified normal CD4+ T cells activated via T-cell receptor (immobilized anti-CD3 and …
psoriatic lesions. In this study, we determined whether cytokines released by epidermal cells
from psoriatic lesions are providing signals that result in propagation of intralesional T-cell
activation. Supernatants were obtained from epidermal cell cultures derived from skin biopsy
specimens of psoriatic patients and normal subjects. These supernatants were added to
purified normal CD4+ T cells activated via T-cell receptor (immobilized anti-CD3 and …