[HTML][HTML] Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell line

A Vilà-Brau, AL De Sousa-Coelho… - Journal of Biological …, 2011 - ASBMB
HMGCS2 (hydroxymethylglutaryl CoA synthase 2), the gene that regulates ketone body
production, is barely expressed in cultured cell lines. In this study, we restored HMGCS2
expression and activity in HepG2 cells, thus showing that the wild type enzyme can induce
fatty acid β-oxidation (FAO) and ketogenesis, whereas a catalytically inactive mutant C166A
did not generate either process. Peroxisome proliferator-activated receptor (PPAR) α
expression also induces fatty acid β-oxidation and endogenous HMGCS2 expression …