If we know so much about preeclampsia, why haven't we cured the disease?
JM Roberts, MJ Bell - Journal of reproductive immunology, 2013 - Elsevier
Preeclampsia has been recognized for at least 100 years. In the last 20 years, the
consideration of the disorder as more than simply hypertension in pregnancy has led to an
explosion in knowledge about preeclampsia pathophysiology. It is now evident that for most
cases of preeclampsia, the root cause is the placenta. Relatively reduced placental
perfusion leads to inflammation, oxidative stress, and endoplasmic reticulum stress, which
converge to modify maternal physiology, with endothelium an important target. Although …
consideration of the disorder as more than simply hypertension in pregnancy has led to an
explosion in knowledge about preeclampsia pathophysiology. It is now evident that for most
cases of preeclampsia, the root cause is the placenta. Relatively reduced placental
perfusion leads to inflammation, oxidative stress, and endoplasmic reticulum stress, which
converge to modify maternal physiology, with endothelium an important target. Although …