[HTML][HTML] Regulation of the transforming growth factor β-responsive transcription factor CTF-1 by calcineurin and calcium/calmodulin-dependent protein kinase IV
A Alevizopoulos, Y Dusserre, U Ruegg… - Journal of Biological …, 1997 - ASBMB
Transforming growth factor β (TGF-β) is a pluripotent peptide hormone that regulates various
cellular activities, including growth, differentiation, and extracellular matrix protein gene
expression. We previously showed that TGF-β induces the transcriptional activation domain
(TAD) of CTF-1, the prototypic member of the CTF/NF-I family of transcription factors. This
induction correlates with the proposed role of CTF/NF-I binding sites in collagen gene
induction by TGF-β. However, the mechanisms of TGF-β signal transduction remain poorly …
cellular activities, including growth, differentiation, and extracellular matrix protein gene
expression. We previously showed that TGF-β induces the transcriptional activation domain
(TAD) of CTF-1, the prototypic member of the CTF/NF-I family of transcription factors. This
induction correlates with the proposed role of CTF/NF-I binding sites in collagen gene
induction by TGF-β. However, the mechanisms of TGF-β signal transduction remain poorly …