[HTML][HTML] Distinct roles of inositol 1, 4, 5-trisphosphate receptor types 1 and 3 in Ca2+ signaling
M Hattori, AZ Suzuki, T Higo, H Miyauchi… - Journal of Biological …, 2004 - ASBMB
Three subtypes of inositol 1, 4, 5-trisphosphate receptor (IP 3 R1, IP 3 R2, and IP 3 R3) Ca
2+ release channel share basic properties but differ in terms of regulation. To what extent
they contribute to complex Ca 2+ signaling, such as Ca 2+ oscillations, remains largely
unknown. Here we show that HeLa cells express comparable amounts of IP 3 R1 and IP 3
R3, but knockdown by RNA interference of each subtype results in dramatically distinct Ca
2+ signaling patterns. Knockdown of IP 3 R1 significantly decreases total Ca 2+ signals and …
2+ release channel share basic properties but differ in terms of regulation. To what extent
they contribute to complex Ca 2+ signaling, such as Ca 2+ oscillations, remains largely
unknown. Here we show that HeLa cells express comparable amounts of IP 3 R1 and IP 3
R3, but knockdown by RNA interference of each subtype results in dramatically distinct Ca
2+ signaling patterns. Knockdown of IP 3 R1 significantly decreases total Ca 2+ signals and …