[HTML][HTML] Camstatins are peptide antagonists of calmodulin based upon a conserved structural motif in PEP-19, neurogranin, and neuromodulin
JR Slemmon, JI Morgan, SM Fullerton, W Danho… - Journal of Biological …, 1996 - ASBMB
Unbridled increases in intracellular ionized calcium can result in neuronal damage and
death. Since many of the deleterious effects of calcium are mediated by calmodulin, we have
sought to identify neuronal proteins that inhibit activation of this ubiquitous protein. PEP-19
is a 7.6-kDa neuron-specific protein, which contains a motif similar to the calmodulin binding
domains of neuromodulin (GAP-43) and neurogranin (RC3). Here we show that PEP-19
binds calmodulin in an analogous calcium-independent manner with an apparent K d near …
death. Since many of the deleterious effects of calcium are mediated by calmodulin, we have
sought to identify neuronal proteins that inhibit activation of this ubiquitous protein. PEP-19
is a 7.6-kDa neuron-specific protein, which contains a motif similar to the calmodulin binding
domains of neuromodulin (GAP-43) and neurogranin (RC3). Here we show that PEP-19
binds calmodulin in an analogous calcium-independent manner with an apparent K d near …