[HTML][HTML] CCAAT-enhancer-binding protein β (C/EBPβ) and downstream human placental growth hormone genes are targets for dysregulation in pregnancies …
H Vakili, Y Jin, S Menticoglou, PA Cattini - Journal of Biological Chemistry, 2013 - ASBMB
Human chorionic somatomammotropin (CS) and placental growth hormone variant (GH-V)
act as metabolic adaptors in response to maternal insulin resistance, which occurs in"
normal" pregnancy. Maternal obesity can exacerbate this" resistance," suggesting that CS,
GH-V, or transcription factors that regulate their production might be targets. The human CS
genes, hCS-A and hCS-B, flank the GH-V gene. A significant decrease in pre-term placental
CS/GH-V RNA levels was observed in transgenic mice containing the CS/GH-V genes in a …
act as metabolic adaptors in response to maternal insulin resistance, which occurs in"
normal" pregnancy. Maternal obesity can exacerbate this" resistance," suggesting that CS,
GH-V, or transcription factors that regulate their production might be targets. The human CS
genes, hCS-A and hCS-B, flank the GH-V gene. A significant decrease in pre-term placental
CS/GH-V RNA levels was observed in transgenic mice containing the CS/GH-V genes in a …