The molecular basis for growth hormone–receptor interactions
JA WELLS, BC CUNNINGHAM, G FUH… - Recent Progress in …, 1993 - Elsevier
Publisher Summary This chapter discusses the molecular basis for growth hormone (GH)–
receptor interactions. A high-resolution mutational and structural analyses of purified
components have revealed a great deal about the molecular basis for GH action. The
structural and functional aspects of the interactions between hGH and its receptors have
been largely elaborated. From these studies, it has been possible to engineer homologs of
hGH to bind to the hGH receptor and act as potential antagonists. Receptor-selective and …
receptor interactions. A high-resolution mutational and structural analyses of purified
components have revealed a great deal about the molecular basis for GH action. The
structural and functional aspects of the interactions between hGH and its receptors have
been largely elaborated. From these studies, it has been possible to engineer homologs of
hGH to bind to the hGH receptor and act as potential antagonists. Receptor-selective and …