[HTML][HTML] Adenovirus-mediated bcl-2 gene transfer inhibits renal ischemia/reperfusion induced tubular oxidative stress and apoptosis
C Chiang-Ting, C Tzu-Ching, T Ching-Yi… - American journal of …, 2005 - Elsevier
Ischemia/reperfusion induces oxidative injury to proximal and distal renal tubular cells. We
hypothesize that Bcl-2 protein augmentation with adenovirus vector mediated bcl-2 (Adv-bcl-
2) gene transfer may improve ischemia/reperfusion induced renal proximal and distal
tubular apoptosis through the mitochondrial control of Bax and cytochrome C translocation.
Twenty-four hours of Adv-bcl-2 transfection to proximal and distal tubular cells in vitro
upregulated Bcl-2/Bax ratio and inhibited hypoxia/reoxygenation induced cytochrome C …
hypothesize that Bcl-2 protein augmentation with adenovirus vector mediated bcl-2 (Adv-bcl-
2) gene transfer may improve ischemia/reperfusion induced renal proximal and distal
tubular apoptosis through the mitochondrial control of Bax and cytochrome C translocation.
Twenty-four hours of Adv-bcl-2 transfection to proximal and distal tubular cells in vitro
upregulated Bcl-2/Bax ratio and inhibited hypoxia/reoxygenation induced cytochrome C …