IL-33–activated dendritic cells induce an atypical TH2-type response
MA Rank, T Kobayashi, H Kozaki, KR Bartemes… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: IL-33, a recently discovered IL-1 family cytokine, is implicated in the
development of TH2-type responses in vivo. However, the cellular targets for IL-33 are
poorly understood. OBJECTIVE: We tested the hypotheses that dendritic cells (DCs)
respond to IL-33 and that IL-33–activated DCs prime naive CD4+ T cells to produce TH2-
type cytokines. METHODS: Dendritic cells were derived from mouse bone marrow, and their
expression of the IL-33 receptor, ST2, was examined by fluorescence-activated cell sorting …
development of TH2-type responses in vivo. However, the cellular targets for IL-33 are
poorly understood. OBJECTIVE: We tested the hypotheses that dendritic cells (DCs)
respond to IL-33 and that IL-33–activated DCs prime naive CD4+ T cells to produce TH2-
type cytokines. METHODS: Dendritic cells were derived from mouse bone marrow, and their
expression of the IL-33 receptor, ST2, was examined by fluorescence-activated cell sorting …