Efficient cytokine-induced IL-13 production by mast cells requires both IL-33 and IL-3
IS Junttila, C Watson, L Kummola, X Chen… - Journal of Allergy and …, 2013 - Elsevier
Background IL-13 is a critical effector cytokine for allergic inflammation. It is produced by
several cell types, including mast cells, basophils, and TH 2 cells. In mast cells and
basophils its induction can be stimulated by cross-linkage of immunoglobulin receptors or
cytokines. The IL-1 family members IL-33 and IL-18 have been linked to induction of IL-13
production by mast cells and basophils. In CD4 TH 2 cells IL-33–mediated production of IL-
13 requires simultaneous signal transducer and activator of transcription (STAT) 5 activation …
several cell types, including mast cells, basophils, and TH 2 cells. In mast cells and
basophils its induction can be stimulated by cross-linkage of immunoglobulin receptors or
cytokines. The IL-1 family members IL-33 and IL-18 have been linked to induction of IL-13
production by mast cells and basophils. In CD4 TH 2 cells IL-33–mediated production of IL-
13 requires simultaneous signal transducer and activator of transcription (STAT) 5 activation …