[HTML][HTML] Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt
B Wegiel, CJ Baty, D Gallo, E Csizmadia… - Journal of Biological …, 2009 - ASBMB
Biliverdin reductase A (BVR) catalyzes the reduction of biliverdin (BV) to bilirubin (BR) in all
cells. Others and we have shown that biliverdin is a potent anti-inflammatory molecule,
however, the mechanism by which BV exerts its protective effects is unclear. We describe
and elucidate a novel finding demonstrating that BVR is expressed on the external plasma
membrane of macrophages (and other cells) where it quickly converts BV to BR. The
enzymatic conversion of BV to BR on the surface by BVR initiates a signaling cascade …
cells. Others and we have shown that biliverdin is a potent anti-inflammatory molecule,
however, the mechanism by which BV exerts its protective effects is unclear. We describe
and elucidate a novel finding demonstrating that BVR is expressed on the external plasma
membrane of macrophages (and other cells) where it quickly converts BV to BR. The
enzymatic conversion of BV to BR on the surface by BVR initiates a signaling cascade …