[HTML][HTML] IQGAP1 binds ERK2 and modulates its activity
M Roy, Z Li, DB Sacks - Journal of Biological Chemistry, 2004 - ASBMB
IQGAP1 binds several proteins including actin, calmodulin, E-cadherin, β-catenin, Cdc42,
Rac1, and CLIP-170. The interaction with these targets enables IQGAP1 to participate in
many cellular functions varying from regulation of the cytoskeleton to gene transcription.
Here we show that extracellular signal-regulated kinase (ERK) 2 binds to IQGAP1. In vitro
analysis with purified proteins demonstrated a direct interaction between ERK2 and
IQGAP1. Moreover, binding occurred in cells as endogenous ERK2 co-immunoprecipitated …
Rac1, and CLIP-170. The interaction with these targets enables IQGAP1 to participate in
many cellular functions varying from regulation of the cytoskeleton to gene transcription.
Here we show that extracellular signal-regulated kinase (ERK) 2 binds to IQGAP1. In vitro
analysis with purified proteins demonstrated a direct interaction between ERK2 and
IQGAP1. Moreover, binding occurred in cells as endogenous ERK2 co-immunoprecipitated …