A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis
M Klagsbrun, A Eichmann - Cytokine & growth factor reviews, 2005 - Elsevier
Nerves and blood vessels resemble each other in their ability to form branching networks.
They are in close proximity suggesting possible molecular interactions. The patterning of
nerves and blood vessels are not random but are regulated by attractive and repulsive cues.
Four major neuronal guidance factors that are sensed by growth cones have been identified,
Semaphorin, Ephrin, Slit and Netrin, and their cognate receptors, neuropilin, Eph,
roundabouts (Robo) and uncoordinated-5 (UNC5). Unexpectedly, these ligand/receptor …
They are in close proximity suggesting possible molecular interactions. The patterning of
nerves and blood vessels are not random but are regulated by attractive and repulsive cues.
Four major neuronal guidance factors that are sensed by growth cones have been identified,
Semaphorin, Ephrin, Slit and Netrin, and their cognate receptors, neuropilin, Eph,
roundabouts (Robo) and uncoordinated-5 (UNC5). Unexpectedly, these ligand/receptor …