Immaturity, perinatal inflammation, and retinopathy of prematurity: a multi-hit hypothesis
O Dammann, MJ Brinkhaus, DB Bartels… - Early human …, 2009 - Elsevier
OBJECTIVE: To explore the relationship among markers of infection/inflammation in their
association with retinopathy of prematurity (ROP). METHODS: We studied clinical
characteristics and 4 single nucleotide polymorphisms in infection/inflammation-associated
genes in a group of 73 children with a gestational age< 32 weeks. Forty-four children (60%)
had ROP, of whom 13 (30% of those with ROP) progressed to stage 3 ROP. No child had
grade 4 or 5 ROP. We employed both descriptive and analytic statistical methods …
association with retinopathy of prematurity (ROP). METHODS: We studied clinical
characteristics and 4 single nucleotide polymorphisms in infection/inflammation-associated
genes in a group of 73 children with a gestational age< 32 weeks. Forty-four children (60%)
had ROP, of whom 13 (30% of those with ROP) progressed to stage 3 ROP. No child had
grade 4 or 5 ROP. We employed both descriptive and analytic statistical methods …