[HTML][HTML] RhoA and ROCK promote migration by limiting membrane protrusions
RA Worthylake, K Burridge - Journal of Biological Chemistry, 2003 - ASBMB
Previously, we and others have shown that RhoA and ROCK signaling are required for
negatively regulating integrin-mediated adhesion and for tail retraction of migrating
leukocytes. This study continues our investigation into the molecular mechanisms
underlying RhoA/ROCK-regulated integrin adhesion. We show that inhibition of ROCK up-
regulates integrin-mediated adhesion, which is accompanied by both increased
phosphotyrosine signaling through Pyk-2 and paxillin and inappropriate membrane …
negatively regulating integrin-mediated adhesion and for tail retraction of migrating
leukocytes. This study continues our investigation into the molecular mechanisms
underlying RhoA/ROCK-regulated integrin adhesion. We show that inhibition of ROCK up-
regulates integrin-mediated adhesion, which is accompanied by both increased
phosphotyrosine signaling through Pyk-2 and paxillin and inappropriate membrane …