Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable …
AJ Fried, I Rauter, SR Dillon, HH Jabara… - Journal of allergy and …, 2011 - jacionline.org
Fig 1, A, shows the location of the missense mutations examined in the TACI protein. The
cysteine-rich domain 1 (CRD1) mutants W40R and D41H, the CRD2 mutant I87N, the
transmembrane domain mutants C172Yand A181E, and the intracellular domain mutants
K188M and V246F were expressed on the surface of 293T cell transfectants at levels
comparable with WT TACI (Fig 1, B). Surface expression of the CRD2 mutants Y79C and
C104R was modestly decreased to approximately half of the wild-type CRD2, whereas that …
cysteine-rich domain 1 (CRD1) mutants W40R and D41H, the CRD2 mutant I87N, the
transmembrane domain mutants C172Yand A181E, and the intracellular domain mutants
K188M and V246F were expressed on the surface of 293T cell transfectants at levels
comparable with WT TACI (Fig 1, B). Surface expression of the CRD2 mutants Y79C and
C104R was modestly decreased to approximately half of the wild-type CRD2, whereas that …