Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom

U Müller, CA Akdis, M Fricker, M Akdis… - Journal of allergy and …, 1998 - Elsevier
Background: Specific immunotherapy with honeybee venom (BV) is highly effective, but
allergic side effects can occur during treatment. Immunotherapy with peptides containing
major T-cell epitopes of the relevant allergen or allergens provides an alternative strategy
without these problems. Objective: The study investigates the immunologic mechanisms and
clinical effects of immunotherapy with T-cell epitope peptides of the major BV allergen, the
phospholipase A2 (PLA). Methods: Five patients with IgE-mediated systemic allergic …