The concept of anti-angiogenesis therapy was introduced by Judah Folkman in 1971 and
since then, a plethora of pro-and anti-angiogenic factors have been identified. In the recent
years, it has become clear that angiogenesis, the formation of new capillaries from a pre-
existing capillary network, is highly regulated by the action of pro-and anti-angiogenic
factors. In the healthy adult organism the “angiogenic-switch” is likely turned “Off”, ie anti-
angiogenic factors are likely counteracting the pro-angiogenic factors resulting in a non …