Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis

NL Smith, KM Rice, EG Bovill… - Blood, The Journal …, 2011 - ashpublications.org
NL Smith, KM Rice, EG Bovill, M Cushman, JC Bis, B McKnight, T Lumley, NL Glazer…
Blood, The Journal of the American Society of Hematology, 2011ashpublications.org
In a recent genome-wide association study, variants in 8 genes were associated with VWF
level, a risk factor for venous thrombosis (VT). In an independent, population-based, case-
control study of incident VT, we tested hypotheses that variants in these genes would be
associated with risk. Cases were 656 women who experienced an incident VT, and controls
comprised 710 women without a history of VT. DNA was obtained from whole blood. Logistic
regression was used to test associations between incident VT and single nucleotide …
Abstract
In a recent genome-wide association study, variants in 8 genes were associated with VWF level, a risk factor for venous thrombosis (VT). In an independent, population-based, case-control study of incident VT, we tested hypotheses that variants in these genes would be associated with risk. Cases were 656 women who experienced an incident VT, and controls comprised 710 women without a history of VT. DNA was obtained from whole blood. Logistic regression was used to test associations between incident VT and single nucleotide polymorphisms (SNPs) in 7 genes not previously shown to be associated with VT. Associations with P < .05 were candidates for replication in an independent case-control study of VT in both sexes. Two of the 7 SNPs tested yielded P < .05: rs1039084 (P = .005) in STXBP5, a novel candidate gene for VT, and rs1063856 (P = .04) in VWF, a gene whose protein level is associated with VT risk. Association results for the remaining 5 variants in SCARA5, STAB2, STX2, TC2N, and CLEC4M were not significant. Both STXBP5 and VWF findings were replicated successfully. Variation in genes associated with VWF levels in the genome-wide association study was found to be independently associated with incident VT.
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