Risk factors for breast cancer: a reanalysis of two case-control studies from 1926 and 1931
Background: The first major case-control study, published by Janet Lane-Claypon in 1926,
provided the first epidemiologic evidence that low fertility increases breast cancer risk. This
study in the United Kingdom was replicated in 1931 by JM Wainwright using a US sample.
Neither study used modern statistical inference to interpret their data. We have evaluated
and reanalyzed data from both studies to assess the validity of the original conclusions
about the etiology of breast cancer. Methods: We abstracted data from the published …
provided the first epidemiologic evidence that low fertility increases breast cancer risk. This
study in the United Kingdom was replicated in 1931 by JM Wainwright using a US sample.
Neither study used modern statistical inference to interpret their data. We have evaluated
and reanalyzed data from both studies to assess the validity of the original conclusions
about the etiology of breast cancer. Methods: We abstracted data from the published …