[HTML][HTML] Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats
Y Yamamoto, S Mochida, N Miyazaki, K Kawai… - Journal of biological …, 2010 - ASBMB
Neurotransmitter release is triggered by Ca 2+ binding to a low affinity Ca 2+ sensor, mostly
synaptotagmin-1, which catalyzes SNARE-mediated synaptic vesicle fusion. Tomosyn
negatively regulates Ca 2+-dependent neurotransmitter release by sequestering target
SNAREs through the C-terminal VAMP-like domain. In addition to the C terminus, the N-
terminal WD40 repeats of tomosyn also have potent inhibitory activity toward Ca 2+-
dependent neurotransmitter release, although the molecular mechanism underlying this …
synaptotagmin-1, which catalyzes SNARE-mediated synaptic vesicle fusion. Tomosyn
negatively regulates Ca 2+-dependent neurotransmitter release by sequestering target
SNAREs through the C-terminal VAMP-like domain. In addition to the C terminus, the N-
terminal WD40 repeats of tomosyn also have potent inhibitory activity toward Ca 2+-
dependent neurotransmitter release, although the molecular mechanism underlying this …