Weibel–Palade bodies (WPBs) are endothelial granules that store von Willebrand factor
(VWF), P-selectin, and other vascular modulators. Endothelial cells secrete WPBs in
response to vascular injury, releasing VWF, which triggers platelet rolling, and externalizing
P-selectin, which activates leukocyte trafficking. Endothelial exocytosis is one of the earliest
responses to vascular damage and plays a pivotal role in thrombosis and inflammation. This
review examines the regulation of WPB exocytosis—the exocytic machinery, activators, and …