Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial
PB Watkins, N Kaplowitz, JT Slattery, CR Colonese… - Jama, 2006 - jamanetwork.com
ContextDuring a clinical trial of a novel hydrocodone/acetaminophen combination, a high
incidence of serum alanine aminotransferase (ALT) elevations was observed. ObjectiveTo
characterize the incidence and magnitude of ALT elevations in healthy participants receiving
4 g of acetaminophen daily, either alone or in combination with selected opioids, as
compared with participants treated with placebo. Design, Setting, and ParticipantsA
randomized, single-blind, placebo-controlled, 5-treatment, parallel-group, inpatient, diet …
incidence of serum alanine aminotransferase (ALT) elevations was observed. ObjectiveTo
characterize the incidence and magnitude of ALT elevations in healthy participants receiving
4 g of acetaminophen daily, either alone or in combination with selected opioids, as
compared with participants treated with placebo. Design, Setting, and ParticipantsA
randomized, single-blind, placebo-controlled, 5-treatment, parallel-group, inpatient, diet …