[HTML][HTML] AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
D Nagata, M Mogi, K Walsh - Journal of Biological Chemistry, 2003 - ASBMB
AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that is regulated by
hypoxia and other cellular stresses that result in diminished cellular ATP levels. Here, we
investigated whether AMPK signaling in endothelial cells has a role in regulating
angiogenesis. Hypoxia induced the activating phosphorylation of AMPK in human umbilical
vein endothelial cells (HUVECs), and AMPK activation was required for the maintenance of
pro-angiogenic Akt signaling under these conditions. Suppression of AMPK signaling …
hypoxia and other cellular stresses that result in diminished cellular ATP levels. Here, we
investigated whether AMPK signaling in endothelial cells has a role in regulating
angiogenesis. Hypoxia induced the activating phosphorylation of AMPK in human umbilical
vein endothelial cells (HUVECs), and AMPK activation was required for the maintenance of
pro-angiogenic Akt signaling under these conditions. Suppression of AMPK signaling …