LKB1 is a tumor suppressor protein whose loss leads to HIF1α-mediated activation of a
proangiogenic program in intestinal polyps. LKB1 is also protein kinase regulator of AMP-
activated protein kinase (AMPK) signaling, which is essential for endothelial cell responses
to tissue ischemia. To discern whether LKB1 signaling is either pro-or antiangiogenic, we
investigated ischemia-induced revascularization in mice that were deficient for LKB1 in Tie2-
Cre-expressing cells. Whereas homozygous deletion of LKB1 led to embryonic lethality …