[HTML][HTML] RAGE (receptor for advanced glycation end products): a central player in the inflammatory response
T Chavakis, A Bierhaus, PP Nawroth - Microbes and Infection, 2004 - Elsevier
The present review focuses on the role of RAGE, the “receptor for advanced glycation end
products”, in the inflammatory response. RAGE is a multiligand receptor that propagates
cellular dysfunction in several inflammatory disorders, in tumors and in diabetes. RAGE is
expressed at low levels in normal tissues, but becomes upregulated at sites where its
ligands accumulate. RAGE may play a dual role in the inflammatory response:(i) interaction
of RAGE on leukocytes or endothelial cells (ECs) with its ligands results in cellular activation …
products”, in the inflammatory response. RAGE is a multiligand receptor that propagates
cellular dysfunction in several inflammatory disorders, in tumors and in diabetes. RAGE is
expressed at low levels in normal tissues, but becomes upregulated at sites where its
ligands accumulate. RAGE may play a dual role in the inflammatory response:(i) interaction
of RAGE on leukocytes or endothelial cells (ECs) with its ligands results in cellular activation …