1, 2, 3, 4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors
SR Klopfenstein, AG Evdokimov, AO Colson… - Bioorganic & medicinal …, 2006 - Elsevier
SR Klopfenstein, AG Evdokimov, AO Colson, NT Fairweather, JJ Neuman, MB Maier…
Bioorganic & medicinal chemistry letters, 2006•ElsevierHigh-throughput screening of the P&GP corporate repository against several protein tyrosine
phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic.
Incorporation of the sulfamic acid onto a 1, 2, 3, 4-tetrahydroisoquinoline scaffold provided a
promising starting point for PTP1B inhibitor design.
phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic.
Incorporation of the sulfamic acid onto a 1, 2, 3, 4-tetrahydroisoquinoline scaffold provided a
promising starting point for PTP1B inhibitor design.
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
Elsevier