Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis
J Correale, A Villa - Journal of neuroimmunology, 2008 - Elsevier
To investigate CD8+ regulatory T cell influence on multiple sclerosis development,
peripheral blood and cerebrospinal fluid (CSF) CD8+ T cell clones (TCCs) recognizing
MBP83–102 and MOG63–87-specific CD4+ T cells were isolated from 20 patients during
acute exacerbations, 15 in remission and 15 controls. Blood and CSF CD8+ regulatory TCC
cloning frequency decreased more during exacerbations than remissions or controls. Target
cell pre-activation significantly enhanced CD8+ T granule-mediated cell killing of CD4+ …
peripheral blood and cerebrospinal fluid (CSF) CD8+ T cell clones (TCCs) recognizing
MBP83–102 and MOG63–87-specific CD4+ T cells were isolated from 20 patients during
acute exacerbations, 15 in remission and 15 controls. Blood and CSF CD8+ regulatory TCC
cloning frequency decreased more during exacerbations than remissions or controls. Target
cell pre-activation significantly enhanced CD8+ T granule-mediated cell killing of CD4+ …