Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats
SW Luckey, DR Petersen - Experimental and molecular pathology, 2001 - Elsevier
Kupffer cells are involved in the pathogenesis of chemically mediated liver injury through
release of biologically active mediators that promote the pathogenic process. The purpose of
this study was to elucidate specific biochemical and molecular changes occurring in Kupffer
cells throughout a time course of carbon tetrachloride (CCl4)-mediated liver injury and
fibrosis. Rats were administered 1 ml/kg of CCl4 (10% v/v olive oil) twice weekly for up to 6
weeks. Plasma alanine aminotransferase values and hematoxylin-and-eosin-and trichrome …
release of biologically active mediators that promote the pathogenic process. The purpose of
this study was to elucidate specific biochemical and molecular changes occurring in Kupffer
cells throughout a time course of carbon tetrachloride (CCl4)-mediated liver injury and
fibrosis. Rats were administered 1 ml/kg of CCl4 (10% v/v olive oil) twice weekly for up to 6
weeks. Plasma alanine aminotransferase values and hematoxylin-and-eosin-and trichrome …