While there is considerable evidence that the ovarian hormone estradiol reduces food intake
in female rats, it is unclear which estrogen receptor (ER) subtype, ERα or ERβ, mediates this
effect. While several studies have demonstrated that activation of ERα, but not ERβ, is
sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding
which receptor subtype is necessary. Here we used the selective ERα and ERß antagonists,
MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of …