[HTML][HTML] The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesicles
J Shi, KV Kandror - Journal of biological chemistry, 2007 - ASBMB
In fat and skeletal muscle cells, insulin-responsive vesicles, or IRVs, deliver glucose
transporter Glut4 and several associated proteins to the plasma membrane in response to
hormonal stimulation. Although the protein composition of the IRVs is well studied, the
mechanism of their formation is unknown. It is believed, however, that the cytoplasmic tails of
the IRV component proteins carry targeting information to this compartment. To test this
hypothesis, we have studied targeting of sortilin, one of the major IRV constituents. We have …
transporter Glut4 and several associated proteins to the plasma membrane in response to
hormonal stimulation. Although the protein composition of the IRVs is well studied, the
mechanism of their formation is unknown. It is believed, however, that the cytoplasmic tails of
the IRV component proteins carry targeting information to this compartment. To test this
hypothesis, we have studied targeting of sortilin, one of the major IRV constituents. We have …