[HTML][HTML] Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells

G Hermey, SJ Keat, P Madsen, C Jacobsen… - Journal of Biological …, 2003 - ASBMB
We previously isolated and sequenced murine sorCS1, a type 1 receptor containing a
Vps10p-domain and a leucine-rich domain. We now show that human sorCS1 has three
isoforms, sorCS1a–c, with completely different cytoplasmic tails and differential expression
in tissues. The b tail shows high identity with that of murine sorCS1b, whereas the a and c
tails have no reported counterparts. Like the Vps10p-domain receptor family members
sortilin and sorLA, sorCS1 is synthesized as a proreceptor that is converted in late Golgi …