Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
X Gao, X Liu, J Xu, C Xue, Y Xue, Y Wang - Journal of bioscience and …, 2014 - Elsevier
Trimethylamine N-oxide (TMAO) is an oxidation product of trimethylamine (TMA) and is
present in many aquatic foods. Here, we investigated the effects of TMAO on glucose
tolerance in high fat diet (HFD)-fed mice. Male C57BL/6 mice were randomly assigned to the
control, high fat (HF), and TMAO groups. The HF group was fed a diet containing 25% fat,
and the TMAO group was fed the HFD plus 0.2% TMAO for 4 weeks. After 3 weeks of
feeding, oral glucose tolerance tests were performed. Dietary TMAO increased fasting …
present in many aquatic foods. Here, we investigated the effects of TMAO on glucose
tolerance in high fat diet (HFD)-fed mice. Male C57BL/6 mice were randomly assigned to the
control, high fat (HF), and TMAO groups. The HF group was fed a diet containing 25% fat,
and the TMAO group was fed the HFD plus 0.2% TMAO for 4 weeks. After 3 weeks of
feeding, oral glucose tolerance tests were performed. Dietary TMAO increased fasting …