Background: It is important to understand whether eating eggs, which are a major source of
dietary choline, results in increased exposure to trimethylamine-N-oxide (TMAO), which is
purported to be a risk factor for developing heart disease. Objective: We determined whether
humans eating eggs generate TMAO and, if so, whether there is an associated increase in a
marker for inflammation [ie, high-sensitivity C-reactive protein (hsCRP)] or increased
oxidation of low-density lipoprotein (LDL). Design: In a longitudinal, double-blind …