Nuclear-targeted inhibition of NF-κB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells
YC Chou, JR Sheu, CL Chung, CY Chen, FL Lin… - Chemico-biological …, 2010 - Elsevier
Aberrant remodeling of the extracellular matrix occurs in many pathological processes, and
its breakdown is mainly accomplished by matrix metalloproteinases (MMPs), which
participate in the course of inflammation and tumor invasion. Nuclear factor-κB (NF-κB), a
key transcription factor for the production of MMP-9, can be activated by various
proinflammatory cytokines and promotes inflammation. In the present study, we investigated
the intracellular mechanism for the inhibitory effects of an analogue of N …
its breakdown is mainly accomplished by matrix metalloproteinases (MMPs), which
participate in the course of inflammation and tumor invasion. Nuclear factor-κB (NF-κB), a
key transcription factor for the production of MMP-9, can be activated by various
proinflammatory cytokines and promotes inflammation. In the present study, we investigated
the intracellular mechanism for the inhibitory effects of an analogue of N …