[HTML][HTML] Interplay between menin and K-Ras in regulating lung adenocarcinoma
Y Wu, ZJ Feng, SB Gao, S Matkar, B Xu… - Journal of Biological …, 2012 - ASBMB
MEN1, which encodes the nuclear protein menin, acts as a tumor suppressor in lung cancer
and is often inactivated in human primary lung adenocarcinoma. Here, we show that the
inactivation of MEN1 is associated with increased DNA methylation at the MEN1 promoter
by K-Ras. On one hand, the activated K-Ras up-regulates the expression of DNA
methyltransferases and enhances the binding of DNA methyltransferase 1 to the MEN1
promoter, leading to increased DNA methylation at the MEN1 gene in lung cancer cells; on …
and is often inactivated in human primary lung adenocarcinoma. Here, we show that the
inactivation of MEN1 is associated with increased DNA methylation at the MEN1 promoter
by K-Ras. On one hand, the activated K-Ras up-regulates the expression of DNA
methyltransferases and enhances the binding of DNA methyltransferase 1 to the MEN1
promoter, leading to increased DNA methylation at the MEN1 gene in lung cancer cells; on …