[HTML][HTML] Inactivation of RASSF1A tumor suppressor gene by aberrant promoter hypermethylation in human pituitary adenomas
ZR Qian, T Sano, K Yoshimoto, S Yamada… - Laboratory …, 2005 - Elsevier
Aberrant promoter methylation and resultant silencing of several tumor suppressor genes
play an important role in the pathogenesis of many tumor types. The human Ras association
domain family 1A gene (RASSF1A), recently cloned from the lung tumor locus at 3p21. 3,
was shown to be frequently inactivated by hypermethylation of its promoter region in a
number of malignancies. We have investigated the expression and epigenetic changes of
this novel universal tumor suppressor gene in pituitary adenomas and correlated the data …
play an important role in the pathogenesis of many tumor types. The human Ras association
domain family 1A gene (RASSF1A), recently cloned from the lung tumor locus at 3p21. 3,
was shown to be frequently inactivated by hypermethylation of its promoter region in a
number of malignancies. We have investigated the expression and epigenetic changes of
this novel universal tumor suppressor gene in pituitary adenomas and correlated the data …