Drug-like properties and the causes of poor solubility and poor permeability
CA Lipinski - Journal of pharmacological and toxicological methods, 2000 - Elsevier
There are currently about 10000 drug-like compounds. These are sparsely, rather than
uniformly, distributed through chemistry space. True diversity does not exist in experimental
combinatorial chemistry screening libraries. Absorption, distribution, metabolism, and
excretion (ADME) and chemical reactivity-related toxicity is low, while biological receptor
activity is higher dimensional in chemistry space, and this is partly explainable by
evolutionary pressures on ADME to deal with endobiotics and exobiotics. ADME is hard to …
uniformly, distributed through chemistry space. True diversity does not exist in experimental
combinatorial chemistry screening libraries. Absorption, distribution, metabolism, and
excretion (ADME) and chemical reactivity-related toxicity is low, while biological receptor
activity is higher dimensional in chemistry space, and this is partly explainable by
evolutionary pressures on ADME to deal with endobiotics and exobiotics. ADME is hard to …