[HTML][HTML] Small ubiquitin-related modifier ligase activity of Mms21 is required for maintenance of chromosome integrity during the unperturbed mitotic cell division cycle …
R Rai, SPMV Varma, N Shinde, S Ghosh… - Journal of Biological …, 2011 - ASBMB
The SUMO ligase activity of Mms21/Nse2, a conserved member of the Smc5/6 complex, is
required for resisting extrinsically induced genotoxic stress. We report that the Mms21
SUMO ligase activity is also required during the unchallenged mitotic cell cycle in
Saccharomyces cerevisiae. SUMO ligase-defective cells were slow growing and
spontaneously incurred DNA damage. These cells required caffeine-sensitive Mec1 kinase-
dependent checkpoint signaling for survival even in the absence of extrinsically induced …
required for resisting extrinsically induced genotoxic stress. We report that the Mms21
SUMO ligase activity is also required during the unchallenged mitotic cell cycle in
Saccharomyces cerevisiae. SUMO ligase-defective cells were slow growing and
spontaneously incurred DNA damage. These cells required caffeine-sensitive Mec1 kinase-
dependent checkpoint signaling for survival even in the absence of extrinsically induced …