[HTML][HTML] Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex
WH McDonald, Y Pavlova, JR Yates… - Journal of Biological …, 2003 - ASBMB
The structural maintenance of chromosomes (SMC) family of proteins play essential roles in
genomic stability. SMC heterodimers are required for sister-chromatid cohesion (Cohesin:
Smc1 & Smc3), chromatin condensation (Condensin: Smc2 & Smc4), and DNA repair (Smc5
& Smc6). The SMC heterodimers do not function alone and must associate with essential
non-SMC subunits. To gain further insight into the essential and DNA repair roles of the
Smc5–6 complex, we have purified fission yeast Smc5 and identified by mass spectrometry …
genomic stability. SMC heterodimers are required for sister-chromatid cohesion (Cohesin:
Smc1 & Smc3), chromatin condensation (Condensin: Smc2 & Smc4), and DNA repair (Smc5
& Smc6). The SMC heterodimers do not function alone and must associate with essential
non-SMC subunits. To gain further insight into the essential and DNA repair roles of the
Smc5–6 complex, we have purified fission yeast Smc5 and identified by mass spectrometry …