Expression of the Norrie disease gene (Ndp) in developing and adult mouse eye, ear, and brain
X Ye, P Smallwood, J Nathans - Gene Expression Patterns, 2011 - Elsevier
The Norrie disease gene (Ndp) codes for a secreted protein, Norrin, that activates canonical
Wnt signaling by binding to its receptor, Frizzled-4. This signaling system is required for
normal vascular development in the retina and for vascular survival in the cochlea. In
mammals, the pattern of Ndp expression beyond the retina is poorly defined due to the low
abundance of Norrin mRNA and protein. Here, we characterize Ndp expression during
mouse development by studying a knock-in mouse that carries the coding sequence of …
Wnt signaling by binding to its receptor, Frizzled-4. This signaling system is required for
normal vascular development in the retina and for vascular survival in the cochlea. In
mammals, the pattern of Ndp expression beyond the retina is poorly defined due to the low
abundance of Norrin mRNA and protein. Here, we characterize Ndp expression during
mouse development by studying a knock-in mouse that carries the coding sequence of …