The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome
FJ Plunkett, O Franzese, LL Belaramani… - Mechanisms of ageing …, 2005 - Elsevier
Patients with X-linked lymphoproliferative syndrome (XLP) experience excessive T cell
proliferation after primary Epstein–Barr virus (EBV) infection, due to mutations in the
signalling lymphocyte activation molecule (SLAM) associated protein (SAP) molecule. We
examined the impact of dysfunctional proliferative control on the extent of CD8+ T cell
differentiation in XLP patients who recovered from primary EBV infection. Although these
young patients have normal numbers of lytic and latent EBV-epitope-specific CD8+ T cells …
proliferation after primary Epstein–Barr virus (EBV) infection, due to mutations in the
signalling lymphocyte activation molecule (SLAM) associated protein (SAP) molecule. We
examined the impact of dysfunctional proliferative control on the extent of CD8+ T cell
differentiation in XLP patients who recovered from primary EBV infection. Although these
young patients have normal numbers of lytic and latent EBV-epitope-specific CD8+ T cells …