Proliferative arrest and cell cycle regulation in CD8+ CD28− versus CD8+ CD28+ T cells
UJ Scheuring, H Sabzevari, AN Theofilopoulos - Human immunology, 2002 - Elsevier
CD8+ CD28− T cells have been characterized by oligoclonal expansions, impaired
proliferative responses, but preserved cytotoxicity and reduced telomeres. To examine this
subset further and define the underlying mechanisms of proliferation arrest, we investigated
several features of this cell type compared with CD8+ CD28+ controls. We analyzed
expression of various activation markers, thymidine incorporation upon activation, T-cell
receptor (TCR) ζ-chain phosphorylation, cell cycle characteristics, and cell cycle related …
proliferative responses, but preserved cytotoxicity and reduced telomeres. To examine this
subset further and define the underlying mechanisms of proliferation arrest, we investigated
several features of this cell type compared with CD8+ CD28+ controls. We analyzed
expression of various activation markers, thymidine incorporation upon activation, T-cell
receptor (TCR) ζ-chain phosphorylation, cell cycle characteristics, and cell cycle related …