[PDF][PDF] A brake becomes an accelerator: PTP1B—a new therapeutic target for breast cancer
NK Tonks, SK Muthuswamy - Cancer cell, 2007 - cell.com
NK Tonks, SK Muthuswamy
Cancer cell, 2007•cell.comThe protein tyrosine phosphatase PTP1B, previously recognized for its role in
downregulating insulin and leptin signaling, has now been shown to function as a positive
regulator of signaling events associated with breast tumorigenesis. Inhibitors of PTP1B that
have been developed as drug candidates for treatment of diabetes and obesity may offer
new avenues for the treatment of breast cancer.
downregulating insulin and leptin signaling, has now been shown to function as a positive
regulator of signaling events associated with breast tumorigenesis. Inhibitors of PTP1B that
have been developed as drug candidates for treatment of diabetes and obesity may offer
new avenues for the treatment of breast cancer.
The protein tyrosine phosphatase PTP1B, previously recognized for its role in downregulating insulin and leptin signaling, has now been shown to function as a positive regulator of signaling events associated with breast tumorigenesis. Inhibitors of PTP1B that have been developed as drug candidates for treatment of diabetes and obesity may offer new avenues for the treatment of breast cancer.
cell.com