Regulation of transient receptor potential (TRP) channels by phosphoinositides
This review summarizes the modulation of transient receptor potential (TRP) channels, by
phosphoinositides. TRP channels are characterized by polymodal activation and a
surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are
modulated by phosphoinositides. Modulation by phosphatidylinositol 4, 5-biphosphate (PIP
2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4,
TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels …
phosphoinositides. TRP channels are characterized by polymodal activation and a
surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are
modulated by phosphoinositides. Modulation by phosphatidylinositol 4, 5-biphosphate (PIP
2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4,
TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels …
Abstract
This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP2 and discusses some future challenges of this fascinating topic.
Springer