[HTML][HTML] Consequences of direct versus indirect activation of epidermal growth factor receptor in intestinal epithelial cells are dictated by protein-tyrosine phosphatase …
DF McCole, A Truong, M Bunz, KE Barrett - Journal of biological chemistry, 2007 - ASBMB
The epidermal growth factor receptor (EGFR) is an integral regulator of many cellular
functions. EGFR also acts as a central conduit for extracellular signals involving direct
activation of the receptor by EGFR ligands or indirect activation by G protein-coupled
receptor (GPCR)-stimulated transactivation of the EGFR. We have previously shown that
EGFR negatively regulates epithelial chloride secretion as a result of transforming growth
factor-α-mediated EGFR transactivation in response to muscarinic GPCR activation. Here …
functions. EGFR also acts as a central conduit for extracellular signals involving direct
activation of the receptor by EGFR ligands or indirect activation by G protein-coupled
receptor (GPCR)-stimulated transactivation of the EGFR. We have previously shown that
EGFR negatively regulates epithelial chloride secretion as a result of transforming growth
factor-α-mediated EGFR transactivation in response to muscarinic GPCR activation. Here …