Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues

V Besnard, SE Wert, WM Hull, JA Whitsett - Gene Expression Patterns, 2004 - Elsevier
Members of the Forkhead box (Fox) transcription factors family Foxa1 (Hnf-3α), Foxa2 (Hnf-
3β) are known to influence gene expression in endodermally derived tissues including lung,
liver, pancreas, stomach, and intestine. In the present study, we have generated highly
specific antibodies for Foxa1 and Foxa2 and determined their expression patterns in the
developing and adult mouse. Foxa1 and Foxa2 were detected in the nuclei of tissues
derived from both foregut and hindgut endoderm (liver, lung, pancreas, stomach, intestine …