Is intestinal metaplasia of the stomach reversible?

MM Walker - Gut, 2003 - gut.bmj.com
MM Walker
Gut, 2003gut.bmj.com
Intestinal metaplasia (IM) of the stomach is a risk factor in developing intestinal-type gastric
cancer and hence the question of reversibility is vital. There is emerging epidemiological
evidence that with long term follow up, IM may be reversible although a combination of
antioxidant agents and eradication of H pylori may be necessary to achieve this. The
pathogenesis of IM is currently being elucidated and it is likely that a combination of
bacterial, host, and environmental factors will be shown to lead to IM. In assessing gastric …
Intestinal metaplasia (IM) of the stomach is a risk factor in developing intestinal-type gastric cancer and hence the question of reversibility is vital. There is emerging epidemiological evidence that with long term follow up, IM may be reversible although a combination of antioxidant agents and eradication of H pylori may be necessary to achieve this. The pathogenesis of IM is currently being elucidated and it is likely that a combination of bacterial, host, and environmental factors will be shown to lead to IM. In assessing gastric cancer risk, histochemical typing of IM will most probably be replaced by molecular markers.
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